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Without adequate treatment, hypertension can lead to serious complications, including heart attack, stroke, and kidney damage. Drug Therapy Options The treatment of high blood pressure usually includes lifestyle-related measures (e.g., weight reduction, salt reduction, physical activity), as well as the administration of antihypertensive agents. The most important groups of Drugs are: ACE inhibitors (Angiotensin‑converting enzyme inhibitors): Inhibit the formation of Angiotensin II, which leads to a dilation of the blood vessels. Examples: Enalapril, Ramipril. Mechanism of action: Blockade of the conversion of Angiotensin I to Angiotensin II → reduction of peripheral vascular resistance. AT1‑receptor blockers (Sartans): Similar effect as ACE inhibitors, however, by direct Blockade of the Angiotensin II receptors. Examples: Losartan, Valsartan. Advantage: Fewer side effects (e.g., less cough than ACE inhibitors). Calcium antagonists: Block the influx of Calcium into the smooth muscle of the vascular wall, which leads to vasodilation. Sub-groups: Dihydropyridines (e.g., amlodipine) Non‑dihydropyridines (e.g., Verapamil, Diltiazem). Beta-blockers: Reduce ejection and the heart rate and the Heart, by blocking the β‑adrenergic receptors. Examples: Metoprolol, Bisoprolol. Use in patients with heart failure or after myocardial infarction. Diuretics (Urine Driver): Increase the excretion of water and salt through the kidneys, which reduces the volume of blood. Types: Thiazides (eg, hydrochlorothiazide) Loop diuretics (e.g., furosemide) Potassium-saving (e.g., spironolactone). Aldosterone antagonists: For example, spironolactone and Eplerenone. Particularly effective in resistant hypertension and in congestive heart failure. Treatment strategy Often, a combination therapy of two or more groups of active substances is used, the blood pressure effectively. The ESC guidelines recommend, for example, as a first-line therapy: a combination of an ACE inhibitor or Sartan with a calcium antagonist or a thiazide diuretic. Side effects and customization Each class of drugs, has potential side effects: ACE‑inhibitors: cough, Hyperkalemia Calcium antagonists: Edema, redness of the face Beta-Blockers: Bradycardia, Fatigue Diuretics: Electrolyte Disorders, Uric Acid Increase The choice of drugs depends on: the individual risk profile (e.g., Diabetes, renal function) concomitant diseases (e.g., congestive heart failure, Asthma) Compatibility and cost. Conclusion The pharmacotherapy of hypertension is diverse and well studied. An individually tailored, evidence-based treatment provides an effective reduction in blood pressure and reduces the risk for cardiovascular events. Regular checks and patient education are crucial for the success of the therapy. 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Our expert team has the most important drugs for the treatment of: High blood pressure, Heart failure, Coronary Heart Disease, Arrhythmias and other cardiovascular diseases in a concise list. What you'll find in our medication list: Accurate information: active ingredients, dosages and application notes. Safety priority: notes on side effects and interactions with other drugs. Timeliness: The list is regularly reviewed and up to date medical research. Clear explanations of Complex technical concepts in a simple and understandable explains. Practical Overview Sorted according to mechanism of action and indication — so that you can quickly find the Right one. Why's our list helps you: Regardless of whether you are affected or a member of support: A reliable information base is the first step to a successful therapy. 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